Helen Papadaki, MD, PhD
Haemopoiesis Research Laboratory, University of Crete Medical School, and
Department of Haematology of the University Hospital of Heraklion
Lab web page:http://haematology.med.uoc.gr
The growth and differentiation of cells in the bone marrow (BM) is regulated by complex interactions between the haemopoietic stem cells (HSCs) and mesenchymal stem cells (MSCs) in highly organized compartments known as “niches”. Our research is focused on the biologic characteristics and the interactions of HSCs and MSCs in normal states and a variety of haematologic diseases.
Specifically, we are interested in:
(a) Characterizing the reserves and functional characteristics of BM-derived HSCs and MSCs in BM failure syndromes and lymphoproliferative diseases with special interest in myelodysplastic and hypoplastic syndromes, chronic neutropenias and low grade lymphomas.
(b) Identifying differences between BM and Wharton Jelly derived MSCs in terms of the molecular and functional properties including the capacity to proliferate and differentiate in biomaterials towards osteocytes and chondrocytes for applications in regenerative medicine.
(c) Investigating the implication of aberrant immune cell populations such as T-cells with skewed T-cell receptor Vβ repertoire profile and myeloid derived suppressor cells, in the pathogenesis of BM failure syndromes.
(d) Studying the therapeutic application of autologous BM-derived MSCs, under GMP conditions, in degenerative diseases.
Our research is funded by grants of EU FP7, Ministries of Education and Development of Hellas, University of Crete Research Secretariat and Pharmaceutical Companies.